Sanes; Development of the Nervous System
Book	Page		Topic
Sanes; Development of the Nervous System	52		Cerebral cortex is not a homogeneous structure, but rather has many distinct regions, each of which has a dedicated function.
Sanes; Development of the Nervous System	52		Brodmann (1909) classified the cerebral cortex into approximately 50 distinct areas.		0
Sanes; Development of the Nervous System	52		Although all neocortex areas have six layers, the relative number of cells in each layer and the size of the layer are quite variable and specialized for the specific function. Visual cortex, a primary sensory area, has many cells in the layer IV the input layer, whereas the motor cortex has very large neurons in layer V, the output layer.		0
Sanes; Development of the Nervous System	55		One particularly well-conserved class of transcription factors, the Hox genes, is important in establishing and maintaining the regional identity of cells and tissues along the anterior posterior axis of vertebrates throughout the hindbrain and spinal cord.		3
Sanes; Development of the Nervous System	59		Cells of the ventricular zone are the precursors of the differentiated neurons and glia of a central nervous system.		4
Sanes; Development of the Nervous System	59		Cells of the ventricular zone undergo from one to two cell cycles per day.		0
Sanes; Development of the Nervous System	59		In the early neural tube, many of the cells undergo symmetric cell divisions, producing two progenitor cells as daughters.    However some of the divisions produce asymmetric daughters:    one daughter continues to divide,    and the other becomes a post mitotic neuron.		0
Sanes; Development of the Nervous System	59		In the spinal cord and in most other areas of the developing neural tube, the postmitotic neurons    migrate from the ventricular zone    to the marginal zone,    where they continue their differentiation.		0
Sanes; Development of the Nervous System	72		Newly generated neurons migrate from the ventricular zone into the cortical plate;    they settle in progressively more peripheral zones.		13
Sanes; Development of the Nervous System	72		Later generated neurons migrate past those generated earlier.		0
Sanes; Development of the Nervous System	72		Inside-out development of cortical layers.		0
Sanes; Development of the Nervous System	73		Inside out pattern of cortical neurogenesis is conserved across mammalian species.		1
Sanes; Development of the Nervous System	73		Crawling of the neuroblast along the radial glial scaffold.		0
Sanes; Development of the Nervous System	85		Progenitor cells    from the early embryonic nervous system    undergo many symmetric cell divisions    to make more progenitor cells,    while the progenitor cells in the late embryo are more likely to undergo asymmetric division    to generate neurons and glia.		12
Sanes; Development of the Nervous System	85		Once the developmental period of neurogenesis is complete,    most areas of the brain do not generate new neurons, even after damage.		0
Sanes; Development of the Nervous System	85		Certain regions of the brain,    the hippocampus and the olfactory bulb,    continue to add new neurons throughout life.		0
Sanes; Development of the Nervous System	85		Continual addition of neurons     in regions such as the hippocampus and olfactory bulb    may allow for greater plasticity in these specific brain circuits.		0
Sanes; Development of the Nervous System	87		Neurons show enormous variety    in cellular anatomy,    physiological function,    neural chemistry,    and conductivity.		2
Sanes; Development of the Nervous System	87		Motor neurons of the spinal cord share a common morphology, chemistry, physiology, and circuitry, yet they are distinctly specified molecularly so that they can connect with particular presynaptic partners and postsynaptic muscles.		0
Sanes; Development of the Nervous System	111		Some neurons, local interneurons, have short axons and make connections to cells in their immediate vicinity, while others, projection neurons, send their axons to distant targets.		24
Sanes; Development of the Nervous System	111		Sensory neurons from the periphery send axons into the CNS where they usually diverge to project to several distinct targets. Each of these targets contains neurons that also diverge to various targets of their own, and so on.		0
Sanes; Development of the Nervous System	111		Tracing backwards on the motor side, each motor neuron is innervated by many presynaptic neurons, and each of these has its own multitude of inputs.		0
Sanes; Development of the Nervous System	111		Pioneer axons navigate in a simpler environment.    As the brain matures,    more axons are added,    and the weave becomes more intricate.    As later axons navigate,    they are aided by pathways laid down by earlier axons.    Rich tapestry of the brain wiring is accomplished by successive addition of new fibers that add complexity in a stepwise fashion.		0
Sanes; Development of the Nervous System
Sanes; Development of the Nervous System
Sanes; Development of the Nervous System
Sanes; Development of the Nervous System
Sanes; Development of the Nervous System
Sanes; Development of the Nervous System
Sanes; Development of the Nervous System
Sanes; Development of the Nervous System
Sanes; Development of the Nervous System
Sanes; Development of the Nervous System
Sanes; Development of the Nervous System
Sanes; Development of the Nervous System